Despite the prevailing discourses on the importance of top management ethical leadership, related theoretical and empirical developments are lacking. Drawing on institutional theory, we propose that top management ethical leadership contributes to organizational outcomes by promoting firm-level ethical and procedural justice climates. This theoretical framework was empirically tested using multi-source data obtained from 4,468 employees of 147 Korean companies from various industries. The firm-level analysis shows that top management ethical leadership significantly predicts ethical climate, which then results in procedural justice (...) climate that fully mediates the effects of top management ethical leadership on two organizational outcomes, namely, firm-level organizational citizenship behavior and firm financial performance. The present study provides a plausible theoretical account and empirical validation of a mechanism through which top management ethical leadership enhances organizational performance. (shrink)

With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics and human research protection beyond Institutional Review Board approval. Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise. Therefore, we developed a simple auditing process and (...) evaluated its feasibility and effectiveness. The screening audit was developed using a routine audit checklist based on the Severance Hospital’s Human Research Protection Program policies and procedures. The measure includes 20 questions, and results are summarized in five categories of audit findings. We analyzed 462 studies that were reviewed by the Severance Hospital Human Research Protection Center between 2013 and 2017. We retrospectively analyzed research characteristics, reply rate, audit findings, associated factors and post-screening audit compliance, etc. Investigator reply rates gradually increased, except for the first year. The studies were graded as “critical,” “major,” “minor,” and “not a finding”, based on findings and number of deficiencies. The auditors’ decisions showed fair agreement with weighted kappa values of 0.316, 0.339, and 0.373. Low-risk level studies, single center studies, and non-phase clinical research showed more prevalent frequencies of being “major” or “critical”. Inappropriateness of documents, failure to obtain informed consent, inappropriateness of informed consent process, and failure to protect participants’ personal information were associated with higher audit grade. We were able to observe critical GCP violations in the routine internal audit results of post-screening audit compliance checks in “non-responding” and “critical” studies upon applying the screening audit. Our screening audit is a simple and effective way to assess overall GCP compliance by institutions and to ensure medical ethics. The tool also provides useful selection criteria for conducting routine audits. (shrink)

Recent years have been marked by major victories for the forces of progress in preventing a military clash between the two opposing worlds - of socialism and of capitalism. But the struggle for détente, for lasting peace and disarmament, naturally does not abolish, nor can it abolish, the ideological struggle that has become noticeably more complicated in its present stage, encompassing within its purview the spheres of economics, politics, law, ethics, and others. Questions of government and democracy predominate in the (...) ideological conflict. (shrink)

Personality disorder symptomatology (PD-Sx) can result in personal distress and impaired interpersonal functioning, even in the absence of a clinical diagnosis, and is frequently comorbid with psychiatric disorders such as substance use, mood, and anxiety disorders; however, they often remain untreated, and are not taken into account in clinical studies. To investigate brain morphological correlates of PD-Sx, we measured subcortical volume and shape, and cortical thickness/surface area, based on structural magnetic resonance images. We investigated 37 subjects who reported PD-Sx exceeding (...) DSM-IV Axis-II screening thresholds, and 35 age, sex, and smoking status-matched control subjects. Subjects reporting PD-Sx were then grouped into symptom-based clusters: N = 20 into Cluster B (reporting Antisocial, Borderline, Histrionic, or Narcissistic PD-Sx) and N = 28 into Cluster C (reporting Obsessive–Compulsive, Avoidant, or Dependent PD-Sx); N = 11 subjects reported PD-Sx from both clusters, and none reported Cluster A (Paranoid, Schizoid, or Schizotypal) PD-Sx. Compared to control, Cluster C PD-Sx was associated with greater striatal surface area localized to the caudate tail, smaller ventral striatum volumes, and greater cortical thickness in right prefrontal cortex. Both Cluster B and C PD-Sx groups also showed trends toward greater posterior caudate volumes and orbitofrontal surface area anomalies, but these findings did not survive correction for multiple comparisons. The results point to morphological abnormalities that could contribute to Cluster C PD-Sx. In addition, the observations parallel those in substance use disorders, pointing to the importance of considering PD-Sx when interpreting findings in often-comorbid psychiatric disorders. (shrink)

Deciphering how DCAFs (DDB1‐CUL4 Associated Factors) modulate a broad spectrum of cellular processes, including cell cycle progression and maintenance of genomic integrity is critical to better understand cellular homeostasis and diseases. Cells contain more than 100 DCAFs that associate with the Cullin‐Ring Ubiquitin Ligase 4 (CRL4) complex that target specific protein substrates for degradation. DCAFs are thought to act as substrate receptors that dictate the specificity of the ubiquitination machinery (“catalytic DCAFs”). However, recent studies have suggested that some DCAFs might (...) play a different role by targeting CRL4 complexes to distinct cellular compartments (“structural DCAFs”). Once localized to their correct cellular domains, these CRLs dissociate from the structural DCAFs prior to their association with other, substrate‐specific catalytic DCAFs. Thus, we propose that DCAF switches can provide a mechanistic basis for the degradation of proteins that regulate cell growth and proliferation at precise points in space and time. (shrink)

Does the Ship of Theseus present a genuine puzzle about persistence due to conflicting intuitions based on “continuity of form” and “continuity of matter” pulling in opposite directions? Philosophers are divided. Some claim that it presents a genuine puzzle but disagree over whether there is a solution. Others claim that there is no puzzle at all since the case has an obvious solution. To assess these proposals, we conducted a cross-cultural study involving nearly 3,000 people across twenty-two countries, speaking eighteen (...) different languages. Our results speak against the proposal that there is no puzzle at all and against the proposal that there is a puzzle but one that has no solution. Our results suggest that there are two criteria—“continuity of form” and “continuity of matter”— that constitute our concept of persistence and these two criteria receive different weightings in settling matters concerning persistence. (shrink)

Nineteenth century hygiene might be a confusing concept. On the one hand, the concept of hygiene was gradually becoming an important concept that was focused on cleanliness and used interchangeably with sanitation. On the other hand, the classical notions of hygiene rooted in the Hippocratic teachings remained influential. This study is about two attempts to newly theorise such a confusing concept of hygiene in the second half of the century by Edward. W. Lane and Thomas R. Allinson. Their works, standing (...) on the borders of self-help medical advice and theoretical treatises on medical philosophies, were not exactly scholarly ones, but their medical thoughts - conceptualised as _hygienic medicine_ - show a characteristically holistic medical view of hygiene, a nineteenth-century version of the reinterpretation of the nature cure philosophy and vitalism. However, the aim of this study is to properly locate their conceptualisations of hygienic medicine within the historical context of the second half of the nineteenth century rather than to simply introduce the medical ideas in their books. Their views of hygiene were distinguished not only from the contemporary sanitary approach but also from similar attempts by contemporary orthodox and unorthodox medical doctors. Through a chronological analysis of changes in the concept of hygiene and a comparative analysis of these two authors’ and other medical professionals’ views of hygiene, this paper aims to help understand the complicated picture of nineteenth-century hygiene, particularly during the second half of the century, from the perspective of medical holism and reductionism. (shrink)

Background We aimed to examine the ethical concerns Singaporeans have about sharing health-data for precision medicine and identify suggestions for governance strategies. Just as Asian genomes are under-represented in PM, the views of Asian populations about the risks and benefits of data sharing are under-represented in prior attitudinal research. Methods We conducted seven focus groups with 62 participants in Singapore from May to July 2019. They were conducted in three languages and analysed with qualitative content and thematic analysis. Results Four (...) key themes emerged: nuanced understandings of data security and data sensitivity; trade-offs between data protection and research benefits; trust in the public and private sectors; and governance and control options. Participants were aware of the inherent risks associated with data sharing for research. Participants expressed conditional support for data sharing, including genomic sequence data and information contained within electronic medical records. This support included sharing data with researchers from universities and healthcare institutions, both in Singapore and overseas. Support was conditional on the perceived social value of the research and appropriate de-identification and data security processes. Participants suggested that a data sharing oversight body would help strengthen public trust and comfort in data research for PM in Singapore. Conclusion Maintenance of public trust in data security systems and governance regimes can enhance participation in PM and data sharing for research. Contrary to themes in much prior research, participants demonstrated a sophisticated understanding of the inherent risks of data sharing, analysed trade-offs between risks and potential benefits of PM, and often adopted an international perspective. (shrink)

Self learning book for beginner on Buddhist debate and dialectic.

The agro-pastoral ecotone, an ecological transition zone connecting adjacent areas of agricultural planting area and grassland animal husbandry, has three features: a complex natural condition, relatively pronounced population pressure, and a fragile ecological environment. In this study, we conducted an ecosystem risk assessment in the western part of Jilin Province, China, based on multiscale and multitemporal remote sensing images and land-use data. Furthermore, we focused on land-use change from 1995 to 2015 by applying the dynamic change information survey method and (...) carrying out a transfer track analysis. The results revealed three main findings. The ecological risk index at the scale of 3 km × 3 km harbors significant spatial correlation. The ecological risk index of unutilized land, forest land, and grassland is relatively high for each, and their anti-interference ability is weak, while the ecological risk index of construction land and water area is the lowest. Human interference, e.g., construction activities and cultivated land occupation, is the leading factor driving the exacerbation of ecological risk and frequent land-use type conversions. At the study period’s end, a trend of slight contraction in the high-risk areas was found, indicating that land-use regulation and land protection policies have had significantly positive impact upon the lands’ ecological value. The overall study identified a reasonable research scale for eco-environmental risk assessment and discerned relationships between regional land-use changes through geospatial analysis. Moreover, our findings can help provide practical case study information applicable to similar regions with agro-pastoral ecotones. (shrink)

Theories of consciousness have a long and controversial history. One well-known proposal — integrated information theory — has recently been labeled as ‘pseudoscience’, which has caused a heated open debate. Here we discuss the case and argue that the theory is indeed unscientific because its core claims are untestable even in principle.

The widespread use of Internet technology has changed people’s traditional life mode and created a new market transaction mode, namely, e-commerce platform. The Internet of Things can carry out real-time monitoring and management of any product in e-commerce and not only can realize information sharing in commercial activities but also can play a greater role in the protection of personal and enterprise information security. In this context, the efficiency and low cost of information flow, cash flow, logistics, and human resources (...) among enterprises are particularly important. The Internet of Things technology is a means to effectively improve and optimize the operation mode of the supply chain. This paper analyzes the status of traditional supply chain management, which discusses the development of a supply chain management based on the Internet of Things technology. Finally, this paper analyzes how to realize the optimization strategy of e-commerce supply chain management based on the Internet of Things technology, which provides strong support for the informatization of e-commerce supply chain management. Through the application of the Internet of Things technology, small- and medium-sized enterprises can optimize the workflow and circulation links of the e-commerce supply chain management, enhance the matching level of product value and information transmission, improve the supply chain operation mechanism, and increase economic benefits. (shrink)

Acetylation of internal lysine residues of core histone N-terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase (HAT) and deacetylase (HDAC) activities strongly suggest that histone acetylation and deacetylation each plays a causative role in regulating transcription. Intriguingly, several HATs have been shown an ability to acetylate nonhistone protein substrates (e.g., transcription factors) in vitro as well, suggesting the possibility that internal (...) lysine acetylation of multiple proteins exists as a rapid and reversible regulatory mechanism much like protein phosphorylation. This article reviews recent developments in histone acetylation and transcriptional regulation. We also discuss several important, yet unanswered, questions. BioEssays 20:615–626, 1998. © 1998 John Wiley & Sons Inc. (shrink)

According to standard Creationism about fictional characters, each fictional character is created by its single author independently, or created by its co-authors cooperatively, or created by its independent authors independently. I argue that standard Creationism faces the Creator-Determining Problem. I propose a non-standard form of Creationism, i.e., Conjunctive Creationism, according to which each fictional character is conjunctively created. I argue that Conjunctive Creationism does not face the Creator-Determining Problem. By responding to four potential worries, I provide a further defense. My (...) conclusion is that Conjunctive Creationism is a more promising form of Creationism.Selon la norme du créationnisme concernant les personnages fictifs, chaque personnage est soit créé indépendamment par son seul auteur, soit créé par ses co-auteurs en collaboration, soit encore créé indépendamment par ses auteurs indépendants. Cette norme doit cependant faire face au problème de l’identification du créateur. Pour éviter ce problème, je propose d’adopter le créationnisme conjonctif, selon lequel chaque personnage est créé conjointement. Je défends cette proposition en répondant à quatre inquiétudes potentielles. Je conclus que le créationnisme conjonctif est une forme plus prometteuse du créationnisme. (shrink)

Resumo: A prática de 70 anos da Nova China mostra que nosso Partido tem, de forma permanente, valorizado e fortalecido a liderança do trabalho ideológico, fator essencial para que a nação chinesa consiga o salto de rica e poderosa, e consolide continuamente a posição dominante do partido. As sucessivas lideranças coletivas do partido exploraram e inovaram a teoria da ideologia socialista em diferentes períodos da história da China, em vista da situação internacional e doméstica, fornecendo ao PCCh uma base teórica (...) científica e diretrizes de ação para romper as barreiras ideológicas em sua regra de longo prazo. Mao Tsé-Tung fez contribuições históricas significativas para explorar o caminho para o novo socialismo chinês, projeto institucional, inovação teórica e construção ideológica. O objetivo deste estudo é combinar os princípios básicos marxismo com a realidade específica da China, apresentar de forma criativa os princípios básicos e as direções básicas da construção da ideología nacional e elaborar sistematicamente a conotação essencial, a ideologia orientadora, os objetivos primários, a natureza fundamental e o camino de realização da construção da ideología socialista. Este estudo mostra que o primeiro salto teórico da localização da ideología marxista na China lançou uma base sólida para construir um país científico e completo e um sistema ideológico nacional científico e completo. (shrink)

This article attempts to introduce the emerging research method of E-textual research into the study of Chinese Buddhism. By outlining the origin and significance of E-textual research, it explores the potential of this endeavour. The application of E-textual research in the field of Buddhism is discussed to clarify its scope and operational procedures. The article also addresses the limitations of E-textual research, stemming from its inherent constraints and the impact of other emerging technologies. E-textual research is not merely a passing (...) trend but offers further avenues for exploration, representing a novel approach for Buddhist studies to engage with new materials and questions in the digital age.Contribution: This article introduces the emerging research method of E-textual research into the study of Chinese Buddhism, outlining its background, operational procedures, existing limitations and future prospects. E-textual research is presented as a new method for addressing new materials and questions in the digital age. (shrink)

This paper aims to clarify and resolve issues surrounding the so-called formal linking problem in interpreting the Internally Headed Relative Clause construction in Korean and Japanese, a problem that has been identified in recent E-type pronominal treatments of the construction (e.g., Hoshi, K. (1995). Structural and interpretive aspects of head-internal and head-external relative clauses. PhD dissertation, University of Rochester; Shimoyama, J. (2001). Wh-constructions in Japanese. PhD dissertation, University of Massachusetts at Amherst). In the literature, this problem refers to the difficulty (...) of capturing the delimited semantic variability of the E-type pronoun present in the embedding clause of the construction. I show that the E-type pronoun at issue is subject to a different licensing condition from a typical E-type pronoun and therefore presents a different linking problem. More specifically, it requires that the embedded clause describe a state of its antecedent and its descriptive content be supplied by a salient property represented in the logical form of the embedded clause. I propose an event-based semantic analysis that derives the effects of this novel generalization by establishing a binding relation between the event structure of the embedded clause and the denotation of the E-type pronoun. (shrink)

Es de sobra conocido que a lo largo de este último siglo se han renovado los estudios platónicos. Este libro quiere contribuir a esta tarea de interpretación de la filosofía de Platón. En primer lugar se clarifica la idoneidad que tiene para comprender a Platón el uso de las llamadas doctrinas no escritas. En segundo lugar se pretende explicar de manera clara y concisa las enseñanzas fundamentales que el filósofo de Atenas por antonomasia quiso dejar por escrito en sus magníficos (...) Diálogos sobre Metafísica, Ética y Política. Tres temáticas que están estrechamente relacionadas en Platón. En tercer y último lugar, el autor propone una reflexión crítica de los grandes hallazgos del pensamiento de Platón a la luz de los avances filosóficos realizados por su discípulo más brillante, Aristóteles. (shrink)

Virtual reality is a rapidly developing technology that simulates the real world. However, for some cybersickness-susceptible people, VR still has an unanswered problem—cybersickness—which becomes the main obstacle for users and content makers. Sensory conflict theory is a widely accepted theory for cybersickness. It proposes that conflict between afferent signals and internal models can cause cybersickness. This study analyzes the brain states that determine cybersickness occurrence and related uncomfortable feelings. Furthermore, we use the electroencephalogram microstates and functional connectivity approach based on (...) the sensory conflict theory. The microstate approach is a time–space analysis method that allows signals to be divided into several temporarily stable states, simultaneously allowing for the exploration of short- and long-range signals. These temporal dynamics can show the disturbances in mental processes associated with neurological and psychiatric conditions of cybersickness. Furthermore, the functional connectivity approach gives us in-depth insight and relationships between the sources related to cybersickness. We recruited 40 males, and they watched a VR video on a curved computer monitor for 10 min to experience cybersickness. We recorded the 5-min resting state EEG and 10-min EEG while watching the VR video. Then, we performed a microstate analysis, focusing on two temporal parameters: mean duration and global explained variance. Finally, we obtained the functional connectivity data using eLoreta and lagged phase synchronization. We discovered five sets of microstates, including four widely reported canonical microstates, during baseline and task conditions. The average duration increased in microstates A and B, which is related to the visual and auditory networks. The GEV and duration decreased in microstate C, whereas those in microstate D increased. Microstate C is related to the default mode network and D to the attention network. The temporal dynamics of the microstate parameters are from cybersickness disturbing the sensory, DMN, and attention networks. In the functional connectivity part, the LPS between the left and right parietal operculum significantly decreased compared with the baseline condition. Furthermore, the connectivity between the right OP and V5 significantly decreased. These results also support the disturbance of the sensory network because a conflict between the visual and vestibular system causes cybersickness. Changes in the microstates and functional connectivity support the sensory conflict theory. These results may provide additional information in understanding brain dynamics during cybersickness. (shrink)

This article introduces a theoretical framework that combines institutional and stakeholder theories to explain how firms choose their corporate social responsibility (CSR) strategy. Organizational researchers have identified several distinct CSR strategies (e.g., obstructionist, defensive, accommodative, and proactive), but did not explain the sources of divergence. This article argues that the divergence comes from the variability in the configuration of external influences that consists of institutional and stakeholder pressures. While institutions affect firms’ social behavior by shaping the macro-level incentive structure and (...) sources of legitimacy (distal mechanisms), firms’ stakeholders can amplify or buffer the institutional forces by acting as mediators (proximate mechanisms). The two dimensions are interdependent in that stakeholders draw legitimacy and power from institutions, and institutions are often actualized through stakeholder mechanisms. Together, they form a particular configuration of external influences that shapes how focal firms construct their CSR strategy. (shrink)

Peripheral vision has different functional priorities for mammals than foveal vision. One of its roles is to monitor the environment while central vision is focused on the current task. Becoming distracted too easily would be counterproductive in this perspective, so the brain should react to behaviourally relevant changes. Gist processing is good for this purpose, and it is therefore not surprising that evidence from both functional brain imaging and behavioural research suggests a tendency to generalize and blend information in the (...) periphery. This may be caused by the balance of perceptual influence in the periphery between bottom-up and top-down processing channels. Here, we investigated this interaction behaviourally using a peripheral numerosity discrimination task with top-down and bottom-up manipulations. Participants compared numerosity between the left and right peripheries of a screen. Each periphery was divided into a centre and a surrounding area, only one of which was a task relevant target region. Our top-down task modulation was the instruction which area to attend – centre or surround. We varied the signal strength by altering the stimuli durations i.e., the amount of information presented/processed. We found that numerosity perceived in target regions was affected by contextual information in neighbouring areas. This effect appeared as soon as stimulus duration allowed the task to be reliably performed and persisted even at the longest duration. We compared the pattern of results with an ideal-observer model and found a qualitative difference in the way centre and surround areas interacted perceptually in the periphery. When participants reported on the central area, the irrelevant surround would affect the response as a weighted combination – consistent with the idea of a receptive field focused in the target area to which irrelevant surround stimulation leaks in. When participants report on surround, we can best describe the response with a model in which occasionally the attention switches from task relevant surround to task irrelevant centre – consistent with a selection model of two competing streams of information. Overall our results show that the influence of spatial context in the periphery is mandatory but task dependent. (shrink)

1. Kwangja chŏngsin e kwanhan kich'ojŏk ihae -- 2. Yuga ŭi kwanggyŏn'gwan -- 3. Toga ŭi kwangŏn kwa kwangja chŏngsin -- 4. Ŭmju munhwa wa Wi-Chin ŭi imt'anjŏk kwang -- 5. Songdae ihakchadŭl ŭi kwangjagwan -- 6. Yangmyŏnghak ŭi kwanggyŏn'gwan -- 7. Chosŏnjo yuhakchadŭl ŭi kwanggyŏn'gwan -- 8. Chosŏnjo yuhakcha ŭi yokki yŏnggwi ihae -- 9. Sŏhwa tot'ongnon kwa kwanggyŏn esŏ chunghaeng ŭro -- 10. Kwanggyŏn mihak ŭi munyejŏk chŏgyong -- 11. Chungguk hoehwa e nat'anan kwanggyŏn mihak -- 12. Chungguk (...) sŏye e nat'anan kwanggyŏn mihak -- 13. Chosŏnjo hoehwa e nat'anan kwanggyŏn mihak -- 14. Chosŏnjo sŏye ŭi kwanggyŏn mihak. (shrink)

Firms worldwide are increasingly required to disclose their carbon emissions due to the environmental damage associated with climate change. Because there has been no previous literature focusing on the determinants of corporate carbon disclosure integrating environmental legitimacy and green innovation, the present study attempted to develop an original framework to fill the research gap. This study explored the influence of environmental legitimacy on corporate carbon disclosure, and investigated the role of green innovation as a mediator. With the samples of Carbon (...) Disclosure Project in China from 2008 to 2012, the results demonstrate that environmental legitimacy significantly negatively influences the likelihood of corporate carbon disclosure, and that green process innovation mediates the relationship, while green product innovation has no significant mediating effect. It means that environmental legitimacy not only directly affects the likelihood of corporate carbon disclosure, but also indirectly affects it via green process innovation. Hence, companies must increase both informal and formal mechanisms, i.e., external environmental legitimacy and internal green process innovation, to engage in carbon information disclosure and ensure sustainability. (shrink)

Despite the increasing number of studies on user experience and user interfaces, few studies have examined emotional interaction between humans and deformable objects. In the current study, we investigated how the anthropomorphic design of a flexible display interacts with emotion. For 101 unique 3D images in which an object was bent at different axes, 281 participants were asked to report how strongly the object evoked five elemental emotions (e.g., happiness, disgust, anger, fear, and sadness) in an online survey. People rated (...) the object’s shape using three emotional categories: happiness, disgust–anger, and sadness–fear. It was also found that a combination of axis of bending (horizontal or diagonal axis) and convexity (bending convexly or concavely) predicted emotional valence, underpinning the anthropomorphic design of flexible displays. Our findings provide empirical evidence that axis of bending and convexity can be an important antecedent of emotional interaction with flexible objects, triggering at least three types of emotion in users. (shrink)

Customers are skeptical about shopping online because e-commerce environments are typically considered impersonal. To assure product quality and to enhance customer proclivity in such environments, post-sale services may be considered to alleviate customers’ skepticism. Therefore, this study’s objective is to investigate the role of an online retailer’s post-sale services on customers’ attitudinal and behavioral aspects. Structural equation modeling is applied to data collected through an online survey answered by 409 online customers of jd.com. Research findings show that product return, exchange, (...) and maintenance services are strongly predictive of online customer satisfaction, and satisfaction significantly impacts customer trust. Both customer satisfaction and trust, as indicators of relationship quality, further mediate the links between product return, exchange, and maintenance services and online customer repurchase intention. In addition, differences between male and female customers were found in various aspects of online retailers’ product return, exchange, and maintenance services. This is the first empirical study that not only examines the influence of all three dimensions of online retailers’ post-sale services on customers’ online shopping perceptions and decisions, but also considers differences between male and female customers. Finally, this research provides theoretical and managerial implications based on conceptual and empirical evidence. (shrink)